Description

Wellbutrin XL Overview

Wellbutrin XL is a prescription antidepressant that contains bupropion hydrochloride and is extended release. It’s prescribed by doctors to treat major depressive disorder (MDD) and to prevent seasonal depressive episodes that occur with seasonal affective disorder (SAD). The official prescribing information labels it an aminoketone antidepressant.

Wellbutrin XL is an extended-release medication, meaning that bupropion is released over time. Therefore, patients should take the prescribing instructions carefully and should not crush, divide or chew the tablet.

What Does Wellbutrin XL Do?

Wellbutrin XL contains bupropion, which acts on certain chemical signalling processes in the brain. Hence, this can help in reducing symptoms associated with depression. But it may take time to work and patients should not alter the dose themselves but should continue to take the exact dose prescribed. MedlinePlus says it takes four weeks or more for some people to get the full benefit of bupropion.

### What is Wellbutrin XL used for?

Wellbutrin XL has two FDA-approved indications. First, doctors prescribe it to treat major depressive disorder. Second, it can be used as a prophylactic of seasonal major depressive episodes in adults with seasonal affective disorder.

Therefore, if Wellbutrin XL is indicated for a patient’s symptoms and medical history, a healthcare provider may consider it.

What strengths are available?

The currently approved label for Wellbutrin XL extended-release tablets lists the following strengths: 150 mg and 300 mg. The right strength will depend on the patient’s condition, how they respond to treatment, their medical history and other medicines.

For major depressive disorder, the labelling recommends an initial dose of 150 mg once daily with a usual target dose of 300 mg once daily. Doctors may make treatment adjustments in individual circumstances. Patients should not increase the dose at any time without medical guidance.

How to Take Wellbutrin XL

Use Wellbutrin XL exactly as directed. Take the tablet with water. Do not crush, chew or break the tablet as this may affect how the extended-release design works. Also, attempt to take it at the same time each day to create a consistent routine.

If you miss a dose, ask your doctor or chemist what you should do. Do not take extra tablets to make up for a missed dose.

What are the common side effects of Wellbutrin XL?

As with other medicines, Wellbutrin XL may cause side effects. Commonly reported reactions on the official label include dry mouth, nausea, insomnia, dizziness, anxiety, agitation, tremor, sweating, headache, abdominal discomfort and palpitations.

Some side effects may get better as the body gets used to the treatment. However, if a side effect becomes severe, persistent or difficult to manage, please contact a healthcare professional.

Who Shouldn’t Take Wellbutrin XL?

Not everyone should take Wellbutrin XL. The official labelling lists several contraindications, including a seizure disorder, current or past diagnosis of bulimia or anorexia nervosa, and abrupt discontinuation of alcohol, benzodiazepines, barbiturates, or certain antiepileptic drugs. It is contraindicated in patients with hypersensitivity to bupropion or its components and in combination with other MAO inhibitors.

Therefore, the patients should inform their complete medication and medical history before starting the treatment.

Important Safety Information

The main concern is the risk of suicidal ideation and behaviour with antidepressant treatment, especially in children, adolescents and young adults. Patients and carers should be alert to the emergence or worsening of symptoms of mood and promptly seek medical attention when such changes occur.

Wellbutrin XL can also increase blood pressure, and lower the seizure threshold. The risk of seizures is dose related, so careful dosing is important. The label also recommends screening for bipolar disorder as treatment with antidepressants can cause mania or hypomania in vulnerable patients.

Does Wellbutrin XL interact with other medicines?

Yes. Wellbutrin XL may interact with other medicines. For example, bupropion can inhibit the CYP2D6 enzyme, and can raise the levels of some antidepressants, antipsychotics, beta-blockers, and other drugs. Special care may also be required with drugs that lower the seizure threshold.

Because of these interactions, talk with your doctor and chemist about all prescription medicines, over-the-counter products, vitamins, and supplements you use or plan to use.

Wellbutrin Xl Frequently Asked Questions

How long does it take for Wellbutrin XL to work?

Some will see the changes before others. But MedlinePlus says it can take four weeks or longer to get the full benefit of bupropion.

Is it safe to stop Wellbutrin XL abruptly?

Do not stop taking Wellbutrin XL on your own. The official labelling has a specific tapering section for stopping treatment and so the prescriber should manage the process.

Is Wellbutrin XL a controlled substance?

Yes. Wellbutrin XL is a prescription antidepressant. It should be used under the guidance of a healthcare professional.

Final thought

Wellbutrin XL is the extended-release formulation of bupropion and is used to treat major depressive disorder and to help prevent seasonal affective disorder depressive episodes. It provides an established treatment option but also has important precautions involving seizures, blood pressure, mood changes and drug interactions. Therefore, patients should only take it as directed and contact a doctor or chemist immediately if they experience any new or unusual symptoms.